[HTML][HTML] FcγRIIb on CD11c+ cells modulates serum cholesterol and triglyceride levels and differentially affects atherosclerosis in male and female Ldlr−/− mice

J Marvin, JP Rhoads, AS Major - Atherosclerosis, 2019 - Elsevier
Background and aims Circulating levels of oxidized lipoprotein (oxLDL) correlate with
myocardial infarction risk and atherosclerosis severity. Our previous study demonstrates that
oxLDL immune complexes (oxLDL-ICs) can signal through FcγRs on bone marrow-derived
dendritic cells (BMDCs) and enhance their activation and inflammatory cytokine secretion.
While global FcγR−/− studies have shown that activating FcγRs are proatherogenic, the role
of the inhibitory FcγRIIb is unclear. We sought to determine the role of DC-specific FcγRIIb in …