Interleukin–10 Expression and Function in Experimental Murine Liver Inflammation and Fibrosis
K Thompson, J Maltby, J Fallowfield, M McAulay… - Hepatology, 1998 - journals.lww.com
Kupffer cells (KC) play a central role in the initiation and perpetuation of hepatic
inflammation, which, if uncontrolled, can result in tissue damage, fibrosis, and cirrhosis.
Interleukin–10 (IL–10) can inhibit a range of macrophage functions. We hypothesized that
the transcription, synthesis, and release of IL–10 may influence the development of liver
injury. Rat KC were activated in vitro with lipopolysaccharide (LPS), and expression of IL–10
mRNA compared with IL–13 and IL–1β by reverse–transcription polymerase chain reaction …
inflammation, which, if uncontrolled, can result in tissue damage, fibrosis, and cirrhosis.
Interleukin–10 (IL–10) can inhibit a range of macrophage functions. We hypothesized that
the transcription, synthesis, and release of IL–10 may influence the development of liver
injury. Rat KC were activated in vitro with lipopolysaccharide (LPS), and expression of IL–10
mRNA compared with IL–13 and IL–1β by reverse–transcription polymerase chain reaction …
