[HTML][HTML] The role of fas/fas ligand system in the pathogenesis of liver cirrhosis and hepatocellular carcinoma
O Hammam, O Mahmoud, M Zahran, S Aly… - Hepatitis …, 2012 - ncbi.nlm.nih.gov
O Hammam, O Mahmoud, M Zahran, S Aly, K Hosny, A Helmy, A Anas
Hepatitis monthly, 2012•ncbi.nlm.nih.govBackground The Fas receptor/ligand system including soluble forms is the most important
apoptotic initiator in the liver. Dysregulation of this pathway may contribute to abnormal cell
proliferation and cell death and is regarded as one of the mechanisms preventing the
immune system from rejecting the tumor cells. Objectives To analyze the role of Fas system
Fas/Fas ligand (Fas/FasL) in the multi-step process of hepatic fibrosis/carcinogenesis, and to
use of the serum markers as possible candidate biomarkers for early detection of …
apoptotic initiator in the liver. Dysregulation of this pathway may contribute to abnormal cell
proliferation and cell death and is regarded as one of the mechanisms preventing the
immune system from rejecting the tumor cells. Objectives To analyze the role of Fas system
Fas/Fas ligand (Fas/FasL) in the multi-step process of hepatic fibrosis/carcinogenesis, and to
use of the serum markers as possible candidate biomarkers for early detection of …
Abstract
Background
The Fas receptor/ligand system including soluble forms is the most important apoptotic initiator in the liver. Dysregulation of this pathway may contribute to abnormal cell proliferation and cell death and is regarded as one of the mechanisms preventing the immune system from rejecting the tumor cells.
Objectives
To analyze the role of Fas system Fas/Fas ligand (Fas/FasL) in the multi-step process of hepatic fibrosis/carcinogenesis, and to use of the serum markers as possible candidate biomarkers for early detection of hepatocellular carcinoma (HCC).
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