[HTML][HTML] Interferon-regulatory factors determine macrophage phenotype polarization
R Günthner, HJ Anders - Mediators of inflammation, 2013 - hindawi.com
R Günthner, HJ Anders
Mediators of inflammation, 2013•hindawi.comThe mononuclear phagocyte system regulates tissue homeostasis as well as all phases of
tissue injury and repair. To do so changing tissue environments alter the phenotype of tissue
macrophages to assure their support for sustaining and amplifying their respective
surrounding environment. Interferon-regulatory factors are intracellular signaling elements
that determine the maturation and gene transcription of leukocytes. Here we discuss how
several among the 9 interferon-regulatory factors contribute to macrophage polarization.
tissue injury and repair. To do so changing tissue environments alter the phenotype of tissue
macrophages to assure their support for sustaining and amplifying their respective
surrounding environment. Interferon-regulatory factors are intracellular signaling elements
that determine the maturation and gene transcription of leukocytes. Here we discuss how
several among the 9 interferon-regulatory factors contribute to macrophage polarization.
The mononuclear phagocyte system regulates tissue homeostasis as well as all phases of tissue injury and repair. To do so changing tissue environments alter the phenotype of tissue macrophages to assure their support for sustaining and amplifying their respective surrounding environment. Interferon-regulatory factors are intracellular signaling elements that determine the maturation and gene transcription of leukocytes. Here we discuss how several among the 9 interferon-regulatory factors contribute to macrophage polarization.
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