[HTML][HTML] Nuclear heme oxygenase-1 (HO-1) modulates subcellular distribution and activation of Nrf2, impacting metabolic and anti-oxidant defenses
C Biswas, N Shah, M Muthu, P La, AP Fernando… - Journal of Biological …, 2014 - ASBMB
With oxidative injury as well as in some solid tumors and myeloid leukemia cells, heme
oxygenase-1 (HO-1), the anti-oxidant, anti-inflammatory, and anti-apoptotic microsomal
stress protein, migrates to the nucleus in a truncated and enzymatically inactive form.
However, the function of HO-1 in the nucleus is not completely clear. Nuclear factor erythroid
2-related factor 2 (Nrf2), a transcription factor and master regulator of numerous antioxidants
and anti-apoptotic proteins, including HO-1, also accumulates in the nucleus with oxidative …
oxygenase-1 (HO-1), the anti-oxidant, anti-inflammatory, and anti-apoptotic microsomal
stress protein, migrates to the nucleus in a truncated and enzymatically inactive form.
However, the function of HO-1 in the nucleus is not completely clear. Nuclear factor erythroid
2-related factor 2 (Nrf2), a transcription factor and master regulator of numerous antioxidants
and anti-apoptotic proteins, including HO-1, also accumulates in the nucleus with oxidative …