Tumor-induced myeloid dysfunction and its implications for cancer immunotherapy

MN Messmer, CS Netherby, D Banik… - Cancer immunology …, 2015 - Springer
MN Messmer, CS Netherby, D Banik, SI Abrams
Cancer immunology, immunotherapy, 2015Springer
Immune function relies on an appropriate balance of the lymphoid and myeloid responses.
In the case of neoplasia, this balance is readily perturbed by the dramatic expansion of
immature or dysfunctional myeloid cells accompanied by a reciprocal decline in the
quantity/quality of the lymphoid response. In this review, we seek to:(1) define the nature of
the atypical myelopoiesis observed in cancer patients and the impact of this perturbation on
clinical outcomes;(2) examine the potential mechanisms underlying these clinical …
Abstract
Immune function relies on an appropriate balance of the lymphoid and myeloid responses. In the case of neoplasia, this balance is readily perturbed by the dramatic expansion of immature or dysfunctional myeloid cells accompanied by a reciprocal decline in the quantity/quality of the lymphoid response. In this review, we seek to: (1) define the nature of the atypical myelopoiesis observed in cancer patients and the impact of this perturbation on clinical outcomes; (2) examine the potential mechanisms underlying these clinical manifestations; and (3) explore potential strategies to restore normal myeloid cell differentiation to improve activation of the host antitumor immune response. We posit that fundamental alterations in myeloid homeostasis triggered by the neoplastic process represent critical checkpoints that govern therapeutic efficacy, as well as offer novel cellular-based biomarkers for tracking changes in disease status or relapse.
Springer