[HTML][HTML] Deletion of selenoprotein M leads to obesity without cognitive deficits

MW Pitts, MA Reeves, AC Hashimoto, A Ogawa… - Journal of Biological …, 2013 - ASBMB
Selenium is an essential trace element that is co-translationally incorporated into
selenoproteins in the form of the 21st amino acid, selenocysteine. This class of proteins
largely functions in oxidation-reduction reactions and is critically involved in maintaining
proper redox balance essential to health. Selenoprotein M (SelM) is a thioredoxin-like
endoplasmic reticulum-resident protein that is highly expressed in the brain and possesses
neuroprotective properties. In this study, we first assessed the regional pattern of SelM …