[HTML][HTML] MicroRNA-378 targets the myogenic repressor MyoR during myoblast differentiation
MicroRNAs play important roles in many cell processes, including the differentiation process
in several different lineages. For example, microRNAs can promote differentiation by
repressing negative regulators of transcriptional activity. These regulated transcription
factors can further up-regulate levels of the microRNA in a feed-forward mechanism. Here
we show that MyoD up-regulates miR-378 during myogenic differentiation in C2C12 cells.
ChIP and high throughput sequencing analysis shows that MyoD binds in close proximity to …
in several different lineages. For example, microRNAs can promote differentiation by
repressing negative regulators of transcriptional activity. These regulated transcription
factors can further up-regulate levels of the microRNA in a feed-forward mechanism. Here
we show that MyoD up-regulates miR-378 during myogenic differentiation in C2C12 cells.
ChIP and high throughput sequencing analysis shows that MyoD binds in close proximity to …