Metformin inhibits ovarian cancer growth and increases sensitivity to paclitaxel in mouse models

E Lengyel, LM Litchfield, AK Mitra, KM Nieman… - American journal of …, 2015 - Elsevier
Objective There is increasing preclinical evidence indicating that metformin, a medication
commonly used for type 2 diabetes mellitus, may protect against cancer. Motivated by this
emerging evidence we asked 2 questions:(1) can metformin prevent ovarian cancer growth
by altering metabolism and (2) will metformin increase sensitivity to chemotherapy. Study
Design The effect of metformin in ovarian cancer was tested in vitro and with 2 different
mouse models. In vitro, cell lines (n= 6) were treated with metformin (10-40 mmol/L) or …