Recombinant human serum amyloid P in healthy volunteers and patients with pulmonary fibrosis

MR Dillingh, B van den Blink, M Moerland… - Pulmonary …, 2013 - Elsevier
Abstract PRM-151, recombinant human Pentraxin-2 (PTX-2) also referred to as serum
amyloid P (SAP), is under development for treatment of fibrosis. A First-in-Human (FIH) trial
was performed to assess the safety, tolerability, and pharmacokinetics of single ascending
intravenous doses of PRM-151 administered to healthy subjects, using a randomized,
blinded, placebo controlled study design. Each cohort included three healthy subjects (PRM-
151: placebo; 2: 1). SAP levels were assessed using a validated ELISA method, non …