Improved survival and amelioration of nephrotoxic nephritis in intercellular adhesion molecule-1 knockout mice.

U Janssen, T Ostendorf, S Gaertner… - Journal of the …, 1998 - journals.lww.com
Abstract Intercellular adhesion molecule-1 (ICAM-1) expression is upregulated in
nephrotoxic nephritis, a model of human rapidly progressive glomerulonephritis. To evaluate
the pathogenetic relevance of ICAM-1 in this model, nephrotoxic nephritis was induced in
ICAM-1 knockout mice and genetic controls. Mice were preimmunized with rabbit IgG in
complete Freund's adjuvant. Seven days later they received rabbit anti-mouse glomerular
basement membrane IgG. The early humoral immune responses (levels of circulating …