Inhibitors of c-Jun N-terminal kinases: an update
Journal of medicinal chemistry, 2015•ACS Publications
The c-Jun N-terminal kinases (JNKs) are serine/threonine kinases implicated in the
pathogenesis of various diseases. Recent advances in the development of novel inhibitors
of JNKs will be reviewed. Significant progress in the design of JNK inhibitors displaying
selectivity versus other kinases has been achieved within the past 4 years. However, the
development of isoform selective JNK inhibitors is still an open task.
pathogenesis of various diseases. Recent advances in the development of novel inhibitors
of JNKs will be reviewed. Significant progress in the design of JNK inhibitors displaying
selectivity versus other kinases has been achieved within the past 4 years. However, the
development of isoform selective JNK inhibitors is still an open task.
The c-Jun N-terminal kinases (JNKs) are serine/threonine kinases implicated in the pathogenesis of various diseases. Recent advances in the development of novel inhibitors of JNKs will be reviewed. Significant progress in the design of JNK inhibitors displaying selectivity versus other kinases has been achieved within the past 4 years. However, the development of isoform selective JNK inhibitors is still an open task.
ACS Publications