Conservation of the Duchenne muscular dystrophy gene in mice and humans

EP Hoffman, AP Monaco, CC Feener, LM Kunkel - Science, 1987 - science.org
EP Hoffman, AP Monaco, CC Feener, LM Kunkel
Science, 1987science.org
A portion of the Duchenne muscular dystrophy (DMD) gene transcript from human fetal
skeletal muscle and mouse adult heart was sequenced, representing approximately 25
percent of the total, 14-kb DMD transcript. The nucleic acid and predicted amino acid
sequences from the two species are nearly 90 percent homologous. The amino acid
sequence that is predicted from this portion of the DMD gene indicates that the protein
product might serve a structural role in muscle, but the abundance and tissue distribution of …
A portion of the Duchenne muscular dystrophy (DMD) gene transcript from human fetal skeletal muscle and mouse adult heart was sequenced, representing approximately 25 percent of the total, 14-kb DMD transcript. The nucleic acid and predicted amino acid sequences from the two species are nearly 90 percent homologous. The amino acid sequence that is predicted from this portion of the DMD gene indicates that the protein product might serve a structural role in muscle, but the abundance and tissue distribution of the messenger RNA suggests that the DMD protein is not nebulin.
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