Recently, a number of chemical and drug screens using zebrafish embryos have been
published. Using zebrafish dystrophin mutants, we screened a chemical library for small
molecules that modulate the muscle phenotype and identified seven small molecules that
influence muscle pathology in dystrophin-null zebrafish. One chemical, aminophylline,
which is known to be a non-selective phosphodiesterase (PDE) inhibitor, had the greatest
ability to restore normal muscle structure and to up-regulate cAMP-dependent protein kinase …