Different cytokine and stimulation conditions influence the expansion and immune phenotype of third-generation chimeric antigen receptor T cells specific for tumor …
T Gargett, MP Brown - Cytotherapy, 2015 - Elsevier
Background aims Chimeric antigen receptor (CAR) T cells are a novel immunotherapy for
cancer. To achieve anti-tumor efficacy, these cells must survive, expand, and persist after
infusion into patients, functions that are reportedly best achieved by cells with a stem or
central-memory rather than effector-memory phenotype. We have developed third-
generation CAR T cells specific for the tumor-associated antigen GD2 for use in a phase I
clinical trial. We investigated the optimal cell culture conditions for CAR T-cell production …
cancer. To achieve anti-tumor efficacy, these cells must survive, expand, and persist after
infusion into patients, functions that are reportedly best achieved by cells with a stem or
central-memory rather than effector-memory phenotype. We have developed third-
generation CAR T cells specific for the tumor-associated antigen GD2 for use in a phase I
clinical trial. We investigated the optimal cell culture conditions for CAR T-cell production …