[HTML][HTML] Intracellular replication of attenuated Mycobacterium tuberculosis phoP mutant in the absence of host cell cytotoxicity
NL Ferrer, AB Gómez, CY Soto, O Neyrolles… - Microbes and …, 2009 - Elsevier
Intracellular pathogen Mycobacterium tuberculosis survives and replicates in macrophages
but limited information is available on its replication into non-phagocytic cells. Here we study
the role of the M. tuberculosis virulence gene phoP in the intracellular growth with rat and
human lung fibroblasts. In contrast to macrophages, attenuated M. tuberculosis phoP mutant
was able to multiply intracellularly in fibroblasts at the same level as the virulent M.
tuberculosis. However, when M. tuberculosis virulence was studied using human foetal lung …
but limited information is available on its replication into non-phagocytic cells. Here we study
the role of the M. tuberculosis virulence gene phoP in the intracellular growth with rat and
human lung fibroblasts. In contrast to macrophages, attenuated M. tuberculosis phoP mutant
was able to multiply intracellularly in fibroblasts at the same level as the virulent M.
tuberculosis. However, when M. tuberculosis virulence was studied using human foetal lung …