Transient suppression of macrophage functions by liposome-encapsulated drugs

N van Rooijen, J Bakker, N Sanders - Trends in biotechnology, 1997 - cell.com
N van Rooijen, J Bakker, N Sanders
Trends in biotechnology, 1997cell.com
Macrophages play an important role in host defense reactions, for example, by phagocytosis
of particulate materials. This process also results in the rapid removal of targeting devices
such as liposomes and adenovirus vectors and of nonautologous grafted cells and
materials. Another aspect of macrophage function is their production and secretion of
proinflammatory cytokines. Transient and organspecific suppression of macrophage function
by liposome-mediated manipulation has been shown to improve the efficacy of drug and …
Macrophages play an important role in host defense reactions, for example, by phagocytosis of particulate materials. This process also results in the rapid removal of targeting devices such as liposomes and adenovirus vectors and of nonautologous grafted cells and materials. Another aspect of macrophage function is their production and secretion of proinflammatory cytokines. Transient and organspecific suppression of macrophage function by liposome-mediated manipulation has been shown to improve the efficacy of drug and gene targeting and to reduce the symptoms of inflammatory reactions.
cell.com