Cardiovascular autophagy: concepts, controversies, and perspectives
Autophagy, 2013•Taylor & Francis
Despite recent scientific and technological advances, cardiovascular disease remains the
leading cause of morbidity and mortality worldwide. Autophagy, an evolutionarily ancient
response to cellular stress, has been implicated in the pathogenesis of a wide range of heart
pathologies. However, the precise role of autophagy in these contexts remains obscure
owing to its multifarious actions. Here, we review recently derived insights regarding the role
of autophagy in multiple manifestations of cardiac plasticity and disease.
leading cause of morbidity and mortality worldwide. Autophagy, an evolutionarily ancient
response to cellular stress, has been implicated in the pathogenesis of a wide range of heart
pathologies. However, the precise role of autophagy in these contexts remains obscure
owing to its multifarious actions. Here, we review recently derived insights regarding the role
of autophagy in multiple manifestations of cardiac plasticity and disease.
Despite recent scientific and technological advances, cardiovascular disease remains the leading cause of morbidity and mortality worldwide. Autophagy, an evolutionarily ancient response to cellular stress, has been implicated in the pathogenesis of a wide range of heart pathologies. However, the precise role of autophagy in these contexts remains obscure owing to its multifarious actions. Here, we review recently derived insights regarding the role of autophagy in multiple manifestations of cardiac plasticity and disease.
Taylor & Francis Online