[HTML][HTML] Intestinal CD103+ CD11b− dendritic cells restrain colitis via IFN-γ-induced anti-inflammatory response in epithelial cells
ARBM Muzaki, P Tetlak, J Sheng, SC Loh… - Mucosal …, 2016 - Elsevier
A crosstalk between commensals, gut immune cells, and colonic epithelia is required for a
proper function of intestinal mucosal barrier. Here we investigated the importance of two
distinct intestinal dendritic cell (DC) subsets in controlling intestinal inflammation. We show
that Clec9A–diphtheria toxin receptor (DTR) mice after depletion of CD103+ CD11b− DCs
developed severe, low-dose dextran sodium sulfate (DSS)-induced colitis, whereas the lack
of CD103+ CD11b+ DCs in Clec4a4-DTR mice did not exacerbate intestinal inflammation …
proper function of intestinal mucosal barrier. Here we investigated the importance of two
distinct intestinal dendritic cell (DC) subsets in controlling intestinal inflammation. We show
that Clec9A–diphtheria toxin receptor (DTR) mice after depletion of CD103+ CD11b− DCs
developed severe, low-dose dextran sodium sulfate (DSS)-induced colitis, whereas the lack
of CD103+ CD11b+ DCs in Clec4a4-DTR mice did not exacerbate intestinal inflammation …