TNF, TNF receptor type 1, and allograft inflammatory factor-1 gene polymorphisms in Japanese patients with type 1 diabetes
M Nishimura, H Obayashi, I Mizuta, H Hara, T Adachi… - Human immunology, 2003 - Elsevier
The human leukocyte antigen (HLA) class III region, located on chromosome 6p21, has
been regarded as one of the susceptible loci for type 1 diabetes. Because it contains many
genes related to inflammatory and immune responses, including tumor necrosis factor
(TNF), lymphotoxin-α (LT-α), and allograft inflammatory factor 1 (AIF-1) genes, it is unclear
which gene within the class III region is responsible for the susceptibility to the disease. We
sequenced the AIF-1 gene region and detected three novel polymorphisms, all of which …
been regarded as one of the susceptible loci for type 1 diabetes. Because it contains many
genes related to inflammatory and immune responses, including tumor necrosis factor
(TNF), lymphotoxin-α (LT-α), and allograft inflammatory factor 1 (AIF-1) genes, it is unclear
which gene within the class III region is responsible for the susceptibility to the disease. We
sequenced the AIF-1 gene region and detected three novel polymorphisms, all of which …
