[HTML][HTML] Dense deposit disease and C3 glomerulopathy
TD Barbour, MC Pickering, HT Cook - Seminars in nephrology, 2013 - Elsevier
C3 glomerulopathy refers to those renal lesions characterized histologically by predominant
C3 accumulation within the glomerulus, and pathogenetically by aberrant regulation of the
alternative pathway of complement. Dense deposit disease is distinguished from other forms
of C3 glomerulopathy by its characteristic appearance on electron microscopy. The extent to
which dense deposit disease also differs from other forms of C3 glomerulopathy in terms of
clinical features, natural history, and outcomes of treatment including renal transplantation is …
C3 accumulation within the glomerulus, and pathogenetically by aberrant regulation of the
alternative pathway of complement. Dense deposit disease is distinguished from other forms
of C3 glomerulopathy by its characteristic appearance on electron microscopy. The extent to
which dense deposit disease also differs from other forms of C3 glomerulopathy in terms of
clinical features, natural history, and outcomes of treatment including renal transplantation is …