DNA damage in protective and adverse inflammatory responses: Friend of foe?
T Poliezhaieva, MA Ermolaeva - Mechanisms of Ageing and Development, 2017 - Elsevier
The impact of DNA damage-induced immune responses on aging and disease development
is a topic of growing scientific interest and debate. While abundant data links persistent
genotoxic stress and associated inflammatory activity to organ decline and cancer
development, evidence of pro-homeostatic nature of immune responses triggered by
transient DNA damage gradually accumulates. Current review focuses on comparing
systemic outcomes of transient genotoxicity with effects of persistent DNA damage from the …
is a topic of growing scientific interest and debate. While abundant data links persistent
genotoxic stress and associated inflammatory activity to organ decline and cancer
development, evidence of pro-homeostatic nature of immune responses triggered by
transient DNA damage gradually accumulates. Current review focuses on comparing
systemic outcomes of transient genotoxicity with effects of persistent DNA damage from the …
