The emerging role of epigenetic modifiers in repair of DNA damage associated with chronic inflammatory diseases
N Ding, AR Maiuri, HM O'Hagan - Mutation Research/Reviews in Mutation …, 2019 - Elsevier
At sites of chronic inflammation epithelial cells are exposed to high levels of reactive oxygen
species (ROS), which can contribute to the initiation and development of many different
human cancers. Aberrant epigenetic alterations that cause transcriptional silencing of tumor
suppressor genes are also implicated in many diseases associated with inflammation,
including cancer. However, it is not clear how altered epigenetic gene silencing is initiated
during chronic inflammation. The high level of ROS at sites of inflammation is known to …
species (ROS), which can contribute to the initiation and development of many different
human cancers. Aberrant epigenetic alterations that cause transcriptional silencing of tumor
suppressor genes are also implicated in many diseases associated with inflammation,
including cancer. However, it is not clear how altered epigenetic gene silencing is initiated
during chronic inflammation. The high level of ROS at sites of inflammation is known to …