Aging of hematopoietic stem cells

G de Haan, SS Lazare - Blood, The Journal of the American …, 2018 - ashpublications.org
G de Haan, SS Lazare
Blood, The Journal of the American Society of Hematology, 2018ashpublications.org
Hematopoietic stem cells (HSCs) ensure a balanced production of all blood cells throughout
life. As they age, HSCs gradually lose their self-renewal and regenerative potential, whereas
the occurrence of cellular derailment strongly increases. Here we review our current
understanding of the molecular mechanisms that contribute to HSC aging. We argue that
most of the causes that underlie HSC aging result from cell-intrinsic pathways, and reflect on
which aspects of the aging process may be reversible. Because many hematological …
Abstract
Hematopoietic stem cells (HSCs) ensure a balanced production of all blood cells throughout life. As they age, HSCs gradually lose their self-renewal and regenerative potential, whereas the occurrence of cellular derailment strongly increases. Here we review our current understanding of the molecular mechanisms that contribute to HSC aging. We argue that most of the causes that underlie HSC aging result from cell-intrinsic pathways, and reflect on which aspects of the aging process may be reversible. Because many hematological pathologies are strongly age-associated, strategies to intervene in aspects of the stem cell aging process may have significant clinical relevance.
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