Heterodimer formation of the myeloid zinc finger 1 SCAN domain and association with promyelocytic leukemia nuclear bodies

LA Noll, FC Peterson, PL Hayes, BF Volkman… - Leukemia research, 2008 - Elsevier
Myeloid zinc finger 1 (MZF1) is a transcription factor that plays an important role in blood cell
development. Previous reports indicate MZF1 is an essential factor whose abnormal
expression results in cancer. However, the molecular mechanisms by which MZF1 functions
in development and contributes to cancer progression remain unknown. MZF1 is a member
of the SCAN domain family of zinc finger proteins (SCAN-ZFP) that form dimers via their
highly conserved SCAN motif. To better understand the molecular mechanism of MZF1 …