Inflammation and epithelial-mesenchymal transition in pancreatic ductal adenocarcinoma: fighting against multiple opponents
FG Khalafalla, MW Khan - Cancer growth and metastasis, 2017 - journals.sagepub.com
Cancer growth and metastasis, 2017•journals.sagepub.com
Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer
and one of the most lethal human cancers. Inflammation is a critical component in PDAC
initiation and progression. Inflammation also contributes to the aggressiveness of PDAC
indirectly via induction of epithelial-mesenchymal transition (EMT), altogether leading to
enhanced resistance to chemotherapy and poor survival rates. This review gives an
overview of the key pro-inflammatory signaling pathways involved in PDAC pathogenesis …
and one of the most lethal human cancers. Inflammation is a critical component in PDAC
initiation and progression. Inflammation also contributes to the aggressiveness of PDAC
indirectly via induction of epithelial-mesenchymal transition (EMT), altogether leading to
enhanced resistance to chemotherapy and poor survival rates. This review gives an
overview of the key pro-inflammatory signaling pathways involved in PDAC pathogenesis …
Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer and one of the most lethal human cancers. Inflammation is a critical component in PDAC initiation and progression. Inflammation also contributes to the aggressiveness of PDAC indirectly via induction of epithelial-mesenchymal transition (EMT), altogether leading to enhanced resistance to chemotherapy and poor survival rates. This review gives an overview of the key pro-inflammatory signaling pathways involved in PDAC pathogenesis and discusses the role of inflammation in induction of EMT and development of chemoresistance in patients with PDAC.
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