The novel secreted adipokine WNT1-inducible signaling pathway protein 2 (WISP2) is a mesenchymal cell activator of canonical WNT
JR Grünberg, A Hammarstedt, S Hedjazifar… - Journal of biological …, 2014 - ASBMB
WNT1-inducible-signaling pathway protein 2 (WISP2) is primarily expressed in
mesenchymal stem cells, fibroblasts, and adipogenic precursor cells. It is both a secreted
and cytosolic protein, the latter regulating precursor cell adipogenic commitment and PPARγ
induction by BMP4. To examine the effect of the secreted protein, we expressed a full-length
and a truncated, non-secreted WISP2 in NIH3T3 fibroblasts. Secreted, but not truncated
WISP2 activated the canonical WNT pathway with increased β-catenin levels, its nuclear …
mesenchymal stem cells, fibroblasts, and adipogenic precursor cells. It is both a secreted
and cytosolic protein, the latter regulating precursor cell adipogenic commitment and PPARγ
induction by BMP4. To examine the effect of the secreted protein, we expressed a full-length
and a truncated, non-secreted WISP2 in NIH3T3 fibroblasts. Secreted, but not truncated
WISP2 activated the canonical WNT pathway with increased β-catenin levels, its nuclear …
