[HTML][HTML] Neural Wiskott-Aldrich Syndrome Protein (N-WASP)-mediated p120-Catenin Interaction with Arp2-Actin Complex Stabilizes Endothelial Adherens Junctions*♦

C Rajput, V Kini, M Smith, P Yazbeck, A Chavez… - Journal of Biological …, 2013 - ASBMB
Stable adherens junctions (AJs) are required for formation of restrictive endothelial barrier.
Vascular endothelial cadherin from contiguous endothelial cells forms AJs, which are
stabilized intracellularly by binding of p120-catenin and cortical actin. Mechanisms inducing
cortical actin formation and enabling its linkage with p120-catenin remain enigmatic. We
altered the function of neural Wiskott-Aldrich syndrome protein (N-WASP), which induces
actin polymerization through actin-related protein 2/3 complex (Arp2/3), to address the role …