The dual role of senescence in pancreatic ductal adenocarcinoma

A Porciuncula, C Hajdu, G David - Advances in Cancer Research, 2016 - Elsevier
The role of senescence as a tumor suppressor is well established; however, recent evidence
has revealed novel paracrine functions for senescent cells in relation to their
microenvironment, most notably protumorigenic roles in certain contexts. Senescent cells
are capable of altering the inflammatory microenvironment through the senescence-
associated secretory phenotype, which could have important consequences for
tumorigenesis. The role of senescent cells in a highly inflammatory cancer like pancreatic …