Follicular helper T cells
Although T cell help for B cells was described several decades ago, it was the identification
of CXCR5 expression by B follicular helper T (Tfh) cells and the subsequent discovery of
their dependence on BCL6 that led to the recognition of Tfh cells as an independent helper
subset and accelerated the pace of discovery. More than 20 transcription factors, together
with RNA-binding proteins and microRNAs, control the expression of chemotactic receptors
and molecules important for the function and homeostasis of Tfh cells. Tfh cells prime B cells …
of CXCR5 expression by B follicular helper T (Tfh) cells and the subsequent discovery of
their dependence on BCL6 that led to the recognition of Tfh cells as an independent helper
subset and accelerated the pace of discovery. More than 20 transcription factors, together
with RNA-binding proteins and microRNAs, control the expression of chemotactic receptors
and molecules important for the function and homeostasis of Tfh cells. Tfh cells prime B cells …
