[HTML][HTML] Promotion of β-catenin/Foxo1 signaling ameliorates renal interstitial fibrosis

P Rao, M Pang, X Qiao, H Yu, H Wang, Y Yang… - Laboratory …, 2019 - Elsevier
Transforming growth factor β (TGF-β) is the key cytokine involved in causing fibrosis through
cross-talk with major profibrotic pathways. However, inhibition of TGF-β to prevent fibrosis
would also abrogate its anti-inflammatory and wound-healing effects. β-catenin is a common
co-factor in most TGF-β signaling pathways. β-catenin binds to T-cell factor (TCF) to activate
profibrotic genes and binds to Forkhead box O (Foxo) to promote cell survival under
oxidative stress. Using a proximity ligation assay in human kidney biopsies, we found that β …