[HTML][HTML] Plasminogen activator inhibitor-1 is a transcriptional target of the canonical pathway of Wnt/β-catenin signaling
W He, R Tan, C Dai, Y Li, D Wang, S Hao… - Journal of biological …, 2010 - ASBMB
Plasminogen activator inhibitor-1 (PAI-1) is a multifunctional glycoprotein that plays a critical
role in the pathogenesis of chronic kidney and cardiovascular diseases. Although
transforming growth factor (TGF)-β1 is a known inducer of PAI-1, how it controls PAI-1
expression remains enigmatic. Here we investigated the mechanism underlying TGF-β1
regulation of PAI-1 in kidney tubular epithelial cells (HKC-8). Surprisingly, overexpression of
Smad2 or Smad3 in HKC-8 cells blocked PAI-1 induction by TGF-β1, whereas knockdown of …
role in the pathogenesis of chronic kidney and cardiovascular diseases. Although
transforming growth factor (TGF)-β1 is a known inducer of PAI-1, how it controls PAI-1
expression remains enigmatic. Here we investigated the mechanism underlying TGF-β1
regulation of PAI-1 in kidney tubular epithelial cells (HKC-8). Surprisingly, overexpression of
Smad2 or Smad3 in HKC-8 cells blocked PAI-1 induction by TGF-β1, whereas knockdown of …
