Chronic phototoxicity and aggressive squamous cell carcinoma of the skin in children and adults during treatment with voriconazole

EW Cowen, JC Nguyen, DD Miller, D McShane… - Journal of the American …, 2010 - Elsevier
BACKGROUND: Voriconazole is a broad-spectrum antifungal agent associated with
photosensitivity and accelerated photoaging. A possible link with aggressive squamous cell
carcinoma (SCC) has also been reported. OBJECTIVE: We sought to determine the
incidence and frequency of cutaneous SCC among patients undergoing long-term treatment
with voriconazole who also manifest features of chronic phototoxicity. METHODS: We
conducted a retrospective review of patients who developed one or more squamous cell …