Familial risk and heritability of cancer among twins in Nordic countries
Importance Estimates of familial cancer risk from population-based studies are essential
components of cancer risk prediction. Objective To estimate familial risk and heritability of
cancer types in a large twin cohort. Design, Setting, and Participants Prospective study of 80
309 monozygotic and 123 382 same-sex dizygotic twin individuals (N= 203 691) within the
population-based registers of Denmark, Finland, Norway, and Sweden. Twins were followed
up a median of 32 years between 1943 and 2010. There were 50 990 individuals who died …
components of cancer risk prediction. Objective To estimate familial risk and heritability of
cancer types in a large twin cohort. Design, Setting, and Participants Prospective study of 80
309 monozygotic and 123 382 same-sex dizygotic twin individuals (N= 203 691) within the
population-based registers of Denmark, Finland, Norway, and Sweden. Twins were followed
up a median of 32 years between 1943 and 2010. There were 50 990 individuals who died …