Continuous bone remodeling in response to mechanical loading is critical for skeletal
integrity, and interstitial fluid flow is an important stimulus for osteoblast/osteocyte growth
and differentiation. However, the biochemical signals mediating osteoblast anabolic
responses to mechanical stimulation are incompletely understood. In primary human
osteoblasts and murine MC3T3-E1 cells, we found that fluid shear stress induced rapid
expression of c-fos, fra-1, fra-2, and fosB/ΔfosB mRNAs; these genes encode transcriptional …