[HTML][HTML] Protein kinase G and focal adhesion kinase converge on Src/Akt/β-catenin signaling module in osteoblast mechanotransduction
H Rangaswami, R Schwappacher, T Tran… - Journal of Biological …, 2012 - ASBMB
Mechanical loading of bone induces interstitial fluid flow, leading to fluid shear stress (FSS)
of osteoblasts. FSS rapidly increases the intracellular calcium concentration ([Ca 2+]) and
nitric oxide (NO) synthesis in osteoblasts and activates the protein kinase Akt. Activated Akt
stimulates osteoblast proliferation and survival, but the mechanism (s) leading to Akt
activation is not well defined. Using pharmacological and genetic approaches in primary
human and mouse osteoblasts and mouse MC3T3 osteoblast-like cells, we found that Akt …
of osteoblasts. FSS rapidly increases the intracellular calcium concentration ([Ca 2+]) and
nitric oxide (NO) synthesis in osteoblasts and activates the protein kinase Akt. Activated Akt
stimulates osteoblast proliferation and survival, but the mechanism (s) leading to Akt
activation is not well defined. Using pharmacological and genetic approaches in primary
human and mouse osteoblasts and mouse MC3T3 osteoblast-like cells, we found that Akt …