[HTML][HTML] Bile acid metabolism and signaling in liver disease and therapy
JYL Chiang - Liver research, 2017 - Elsevier
Liver research, 2017•Elsevier
Bile acids play a critical role in the regulation of glucose, lipid, and energy metabolism
through activation of the nuclear bile acid receptor farnesoid X receptor (FXR) and
membrane G protein-coupled bile acid receptor-1 (Gpbar-1, aka TGR5). Agonist activation of
FXR and TGR5 improves insulin and glucose sensitivity and stimulates energy metabolism
to prevent diabetes, obesity, and non-alcoholic fatty liver disease (NAFLD). Bile acids have
both pro-and anti-inflammatory actions through FXR and TGR5 in the intestine and liver. In …
through activation of the nuclear bile acid receptor farnesoid X receptor (FXR) and
membrane G protein-coupled bile acid receptor-1 (Gpbar-1, aka TGR5). Agonist activation of
FXR and TGR5 improves insulin and glucose sensitivity and stimulates energy metabolism
to prevent diabetes, obesity, and non-alcoholic fatty liver disease (NAFLD). Bile acids have
both pro-and anti-inflammatory actions through FXR and TGR5 in the intestine and liver. In …
Abstract
Bile acids play a critical role in the regulation of glucose, lipid, and energy metabolism through activation of the nuclear bile acid receptor farnesoid X receptor (FXR) and membrane G protein-coupled bile acid receptor-1 (Gpbar-1, aka TGR5). Agonist activation of FXR and TGR5 improves insulin and glucose sensitivity and stimulates energy metabolism to prevent diabetes, obesity, and non-alcoholic fatty liver disease (NAFLD). Bile acids have both pro- and anti-inflammatory actions through FXR and TGR5 in the intestine and liver. In the intestine, bile acids activate FXR and TGR5 to stimulate fibroblast growth factor 15 and glucagon-like peptide-1 secretion. FXR and TGR5 agonists may have therapeutic potential for treating liver-related metabolic diseases, such as diabetes and NAFLD.
Elsevier
