Recombinant mitochondrial transcription factor A protein inhibits nuclear factor of activated T cells signaling and attenuates pathological hypertrophy of cardiac …
T Fujino, T Ide, M Yoshida, K Onitsuka, A Tanaka… - Mitochondrion, 2012 - Elsevier
The overexpression of mitochondrial transcription factor A (TFAM) attenuates the decrease
in mtDNA copy number after myocardial infarction, ameliorates pathological hypertrophy,
and markedly improves survival. However, non-transgenic strategy to increase mtDNA for
the treatment of pathological hypertrophy remains unknown. We produced recombinant
human TFAM protein (rhTFAM). rhTFAM rapidly entered into mitochondria of cultured
cardiac myocytes. rhTFAM increased mtDNA and abolished the activation of nuclear factor …
in mtDNA copy number after myocardial infarction, ameliorates pathological hypertrophy,
and markedly improves survival. However, non-transgenic strategy to increase mtDNA for
the treatment of pathological hypertrophy remains unknown. We produced recombinant
human TFAM protein (rhTFAM). rhTFAM rapidly entered into mitochondria of cultured
cardiac myocytes. rhTFAM increased mtDNA and abolished the activation of nuclear factor …