[HTML][HTML] Glutathione peroxidase 4 is required for maturation of photoreceptor cells
T Ueta, T Inoue, T Furukawa, Y Tamaki… - Journal of Biological …, 2012 - ASBMB
Oxidative stress is implicated in the pathologies of photoreceptor cells, and the protective
role of antioxidant enzymes for photoreceptor cells have been well understood. However,
their essentiality has remained unknown. In this study we generated photoreceptor-specific
conditional knock-out (CKO) mice of glutathione peroxidase 4 (GPx4) and showed the
critical role of GPx4 for photoreceptor cells. In the wild-type retina the dominant GPx4
expression was in the mitochondria, indicating the mitochondrial variant was the major GPx4 …
role of antioxidant enzymes for photoreceptor cells have been well understood. However,
their essentiality has remained unknown. In this study we generated photoreceptor-specific
conditional knock-out (CKO) mice of glutathione peroxidase 4 (GPx4) and showed the
critical role of GPx4 for photoreceptor cells. In the wild-type retina the dominant GPx4
expression was in the mitochondria, indicating the mitochondrial variant was the major GPx4 …