Challenges and opportunities of allogeneic donor-derived CAR T cells

Y Yang, E Jacoby, TJ Fry - Current opinion in hematology, 2015 - journals.lww.com
Y Yang, E Jacoby, TJ Fry
Current opinion in hematology, 2015journals.lww.com
In the allogeneic environment, the potential effects of TCR signaling on the efficacy of CAR
could affect the clinical responses with the use of donor-derived CAR T cells. Better
understanding of the functionality of donor-derived T cells for therapy is essential for the
development of universal effector cells for CAR therapy.
Summary
In the allogeneic environment, the potential effects of TCR signaling on the efficacy of CAR could affect the clinical responses with the use of donor-derived CAR T cells. Better understanding of the functionality of donor-derived T cells for therapy is essential for the development of universal effector cells for CAR therapy.
Lippincott Williams & Wilkins