Graft-facilitating doses of ex vivo activated gammadelta T cells do not cause lethal murine graft-vs.-host disease
WR Drobyski, D Majewski, G Hanson - Biology of Blood and Marrow …, 1999 - astctjournal.org
The purpose of this study was to examine the ability of gamma (delta) T cells to cause graft-
vs.-host disease (GVHD) after allogeneic bone marrow transplantation (BMT) and to
determine whether these cells offered any therapeutic advantages relative to alphabeta T
cells. Due to the paucity of naive gamma (delta) T cells in mice and humans, gamma (delta),
T cells (obtained from alpha (beta) T cell-deficient murine donors) were ex vivo activated
and expanded in interleukin (IL)-2 so as to achieve sufficient cell numbers and to serve as a …
vs.-host disease (GVHD) after allogeneic bone marrow transplantation (BMT) and to
determine whether these cells offered any therapeutic advantages relative to alphabeta T
cells. Due to the paucity of naive gamma (delta) T cells in mice and humans, gamma (delta),
T cells (obtained from alpha (beta) T cell-deficient murine donors) were ex vivo activated
and expanded in interleukin (IL)-2 so as to achieve sufficient cell numbers and to serve as a …