The colon-26 carcinoma tumor-bearing mouse as a model for the study of cancer cachexia
A Bonetto, JE Rupert, R Barreto, TA Zimmers - JoVE (Journal of Visualized …, 2016 - jove.com
Cancer cachexia is the progressive loss of skeletal muscle mass and adipose tissue,
negative nitrogen balance, anorexia, fatigue, inflammation, and activation of lipolysis and
proteolysis systems. Cancer patients with cachexia benefit less from anti-neoplastic
therapies and show increased mortality1. Several animal models have been established in
order to investigate the molecular causes responsible for body and muscle wasting as a
result of tumor growth. Here, we describe methodologies pertaining to a well-characterized …
negative nitrogen balance, anorexia, fatigue, inflammation, and activation of lipolysis and
proteolysis systems. Cancer patients with cachexia benefit less from anti-neoplastic
therapies and show increased mortality1. Several animal models have been established in
order to investigate the molecular causes responsible for body and muscle wasting as a
result of tumor growth. Here, we describe methodologies pertaining to a well-characterized …