cAMP and Ca2+ signaling in secretory epithelia: crosstalk and synergism
Abstract The Ca 2+ and cAMP/PKA pathways are the primary signaling systems in secretory
epithelia that control virtually all secretory gland functions. Interaction and crosstalk in Ca 2+
and cAMP signaling occur at multiple levels to control and tune the activity of each other.
Physiologically, Ca 2+ and cAMP signaling operate at 5–10% of maximal strength, but
synergize to generate the maximal response. Although synergistic action of the Ca 2+ and
cAMP signaling is the common mode of signaling and has been known for many years, we …
epithelia that control virtually all secretory gland functions. Interaction and crosstalk in Ca 2+
and cAMP signaling occur at multiple levels to control and tune the activity of each other.
Physiologically, Ca 2+ and cAMP signaling operate at 5–10% of maximal strength, but
synergize to generate the maximal response. Although synergistic action of the Ca 2+ and
cAMP signaling is the common mode of signaling and has been known for many years, we …