[HTML][HTML] SHIP-deficient mice provide insights into the regulation of dendritic cell development and function
L Neill, AH Tien, J Rey-Ladino, CD Helgason - Experimental hematology, 2007 - Elsevier
OBJECTIVE: Dendritic cells (DC) play a critical role in establishment and maintenance of
central and peripheral tolerance. Despite intensive research, our knowledge of the
molecular mechanisms regulating DC development and function is limited, thus hindering
our ability to generate appropriate DC populations for manipulating immune tolerance. We
utilized mice deficient in the SH2-containing inositol-5-phosphatase (SHIP) to examine the
role of cytokine signaling in DC development and function. METHODS: We analyzed the …
central and peripheral tolerance. Despite intensive research, our knowledge of the
molecular mechanisms regulating DC development and function is limited, thus hindering
our ability to generate appropriate DC populations for manipulating immune tolerance. We
utilized mice deficient in the SH2-containing inositol-5-phosphatase (SHIP) to examine the
role of cytokine signaling in DC development and function. METHODS: We analyzed the …