[HTML][HTML] Protein arginine methyltransferase 5 (PRMT5) inhibition induces lymphoma cell death through reactivation of the retinoblastoma tumor suppressor pathway …
J Chung, V Karkhanis, S Tae, F Yan, P Smith… - Journal of Biological …, 2013 - ASBMB
Epigenetic regulation mediated by lysine-and arginine-specific enzymes plays an essential
role in tumorigenesis, and enhanced expression of the type II protein arginine
methyltransferase PRMT5 as well as the polycomb repressor complex PRC2 has been
associated with increased cell proliferation and survival. Here, we show that PRMT5 is
overexpressed in three different types of non-Hodgkin lymphoma cell lines and clinical
samples as well as in mouse primary lymphoma cells and that it up-regulates PRC2 …
role in tumorigenesis, and enhanced expression of the type II protein arginine
methyltransferase PRMT5 as well as the polycomb repressor complex PRC2 has been
associated with increased cell proliferation and survival. Here, we show that PRMT5 is
overexpressed in three different types of non-Hodgkin lymphoma cell lines and clinical
samples as well as in mouse primary lymphoma cells and that it up-regulates PRC2 …