New insights into graft-versus-host disease and graft rejection
E Perkey, I Maillard - Annual Review of Pathology: Mechanisms …, 2018 - annualreviews.org
Allogeneic transplantation of foreign organs or tissues has lifesaving potential, but can lead
to serious complications. After solid organ transplantation, immune-mediated rejection
mandates the use of prolonged global immunosuppression and limits the life span of
transplanted allografts. After bone marrow transplantation, donor-derived immune cells can
trigger life-threatening graft-versus-host disease. T cells are central mediators of alloimmune
complications and the target of most existing therapeutic interventions. We review recent …
to serious complications. After solid organ transplantation, immune-mediated rejection
mandates the use of prolonged global immunosuppression and limits the life span of
transplanted allografts. After bone marrow transplantation, donor-derived immune cells can
trigger life-threatening graft-versus-host disease. T cells are central mediators of alloimmune
complications and the target of most existing therapeutic interventions. We review recent …