Sex and body-type interactions in the regulation of renal sodium transporter levels, urinary excretion, and activity in lean and obese Zucker rats
S Riazi, VK Madala-Halagappa, X Hu, CA Ecelbarger - Gender medicine, 2006 - Elsevier
Background: Female humans and rodents are relatively protected against the development
of hypertension and renal disease. Whether this protection is modified during insulin
resistance and obesity, however, is not known. Objective: Because renal sodium
reabsorption has a central role in determining blood pressure, we hypothesized that lean
female rats would bave reduced renal expression, activity, and urinary excretion of 8 major
sodium transporters/channels. Methods: Lean and obese, male and female Zucker rats (n= 4 …
of hypertension and renal disease. Whether this protection is modified during insulin
resistance and obesity, however, is not known. Objective: Because renal sodium
reabsorption has a central role in determining blood pressure, we hypothesized that lean
female rats would bave reduced renal expression, activity, and urinary excretion of 8 major
sodium transporters/channels. Methods: Lean and obese, male and female Zucker rats (n= 4 …
