WNK1 activates large-conductance Ca2+-activated K+ channels through modulation of ERK1/2 signaling
Y Liu, X Song, Y Shi, Z Shi, W Niu, X Feng… - Journal of the …, 2015 - journals.lww.com
With no lysine (WNK) kinases are members of the serine/threonine kinase family. We
previously showed that WNK4 inhibits renal large-conductance Ca 2+-activated K+(BK)
channel activity by enhancing its degradation through a lysosomal pathway. In this study, we
investigated the effect of WNK1 on BK channel activity. In HEK293 cells stably expressing
the α subunit of BK (HEK-BKα cells), siRNA-mediated knockdown of WNK1 expression
significantly inhibited both BKα channel activity and open probability. Knockdown of WNK1 …
previously showed that WNK4 inhibits renal large-conductance Ca 2+-activated K+(BK)
channel activity by enhancing its degradation through a lysosomal pathway. In this study, we
investigated the effect of WNK1 on BK channel activity. In HEK293 cells stably expressing
the α subunit of BK (HEK-BKα cells), siRNA-mediated knockdown of WNK1 expression
significantly inhibited both BKα channel activity and open probability. Knockdown of WNK1 …
