High-affinity antibody production through the germinal centre (GC) response is a pivotal process in adaptive immunity. Abnormal development of follicular helper T (T_FH) cells can induce the GC response to self-antigens, subsequently leading to autoimmunity. Here we show the transcriptional repressor Capicua/CIC maintains peripheral immune tolerance by suppressing aberrant activation of adaptive immunity. CIC deficiency induces excessive development of T_FH cells and GC responses in a T-cell-intrinsic manner. ETV5 expression is derepressed in Cic null T_FH cells and knockdown of Etv5 suppresses the enhanced T_FH cell differentiation in Cic-deficient CD4⁺ T cells, suggesting that Etv5 is a critical CIC target gene in T_FH cell differentiation. Furthermore, we identify Maf as a downstream target of the CIC–ETV5 axis in this process. These data demonstrate that CIC maintains T-cell homeostasis and negatively regulates T_FH cell development and autoimmunity.