Association of IRF5 polymorphisms with activation of the interferon α pathway
OJ Rullo, JMP Woo, H Wu, ADC Hoftman… - Annals of the rheumatic …, 2010 - Elsevier
Objective The genetic association of interferon regulatory factor 5 (IRF5) with systemic lupus
erythematosus (SLE) susceptibility has been convincingly established. To gain
understanding of the effect of IRF5 variation in individuals without SLE, a study was
undertaken to examine whether such genetic variation predisposes to activation of the
interferon α (IFNα) pathway. Methods Using a computer simulated approach, 14 single
nucleotide polymorphisms (SNPs) and haplotypes of IRF5 were tested for association with …
erythematosus (SLE) susceptibility has been convincingly established. To gain
understanding of the effect of IRF5 variation in individuals without SLE, a study was
undertaken to examine whether such genetic variation predisposes to activation of the
interferon α (IFNα) pathway. Methods Using a computer simulated approach, 14 single
nucleotide polymorphisms (SNPs) and haplotypes of IRF5 were tested for association with …
